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In 2002 the total sum of all hybrids sold in the US was less than 30,000

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

. In 2003 Toyota sold less than 100,000 total hybrids. By 2004 the numbe

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

r was approaching 250,000 and the numbers are accelerating as we speak a

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

more and more models enter the market from nearly all major manufacture

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

rs now.

So, should the oil change industry worry that soon these hybrid

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

will start cutting into sales? Well, currently the cars being sold stil

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

l have motors, a little smaller, but they still have motors. Many oil ch

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ange companies have a standard price for all cars and therefore they act

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ally use less fresh oil, so they make more money and remember with hybri

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ds they have additional systems too.

Thus, oil change companies are in

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

uck because the hybrids have DC motors in them too and they require 0W-3

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

0 to lubricate and keep cool. Meaning the Oil Change Industry is safe st

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ill, for now! If you are in the lubrication industry then you know that

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

he enemy is heat and well in a DC Motor heat is very much the enemy just

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

like in regular engines.

Most of these DC Motors require a top brand s

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

nthetic like Mobil One. One must remember that with chaos comes opportun

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ity and thus the rapid disruptive changes with hybrids in the automotive

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

sector, this does not mean the end of the world for the businesses, in

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

act it also means substantial new business for those companies who stop

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

fighting it and go with the flow of the new innovations and technologies

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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