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One concern that many people have is how to make the move to Canada with younger children. Sue and I came with our kids when they were older - mostly teenagers. So for this article I asked for contributions from some of the peo

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ple we helped move over. I'm pleased to be able to bring you their advice - in their own words wherever possible.

INVOLVING THE KIDS IN DECISIONS

Young kids need to be involved in decisions just as much as older ones. Their w

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

rries may not be easy to express for them but they do need a chance to take part in this in whatever way they can.

"We also made big efforts to include them in the decision process in some way and talked to them about why we w

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

anted to come here and in what ways it could improve all our lives. They have to see some benefit in it too."

RESEARCH TRIPS

"For our boys bringing them on the research trip really helped so they could see where they were com

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ng. It also helped that we had chosen the area we planned to settle so they could even visit the school they were going to attend."

Even if you don't know exactly where you are going to settle, it is a good idea to visit a few

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

schools in likely areas. Your kids will see something of their new life and you will be able to talk about it with them. Schools are friendly places and well used to helping new kids settle in.

KEEPING IN TOUCH WITH HOME

"Kee

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ping in touch with those back home is important too and for us the webcam is really useful. Younger kids cannot "chat" on the phone as we do but they will have a normal chat with grandparents, cousins etc on the webcam. I think

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

it is better getting everybody set up on the system before you leave, trying to do it once you are here is a headache as we have found out. We also encourage people to send stuff through the mail, photos, dvds as they love gett

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ing mail from the UK as it is always something nice!"

TIMING

If you have a choice, when should you time your move? This is an interesting point. One family came in the middle of the school year, actually in the middle of the

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

erm. Their kids started school within a week of arriving. The school was very welcoming and their girls settled in very quickly. By the end of the first week they’d got invites to playdates and sleepovers.

By contrast another

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

amily waited until their children had finished their school year in the UK before coming. This meant that they arrived at the start of the summer. The result was that their children didn’t get to meet many other children until

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

school started in September. On reflection they felt it would have been better to arrive before the school holidays so their kids could meet a few other children.

ACTIVITIES

Canada isn't short of activities for children. Gett

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ng your kids involved in these is another way for them to fit in. The summer, especially if you arrived in the school holidays, is the time to take advantage of summer camps and other organized activities.

"We have tried to ge

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

t them involved with local activities ASAP and arranged LOADS of "playdates" so they could feel settled with their peer group as quickly as possible. It can be a bit grueling but also helped us make friends too."

Be careful no

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

to over commit your time. You will be running your children around in true "soccer mom" style. Let them try out different activities but watch out that you don't spend too much. One parent warned about the cost of (ice) hockey

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

gear for their initially enthusiastic son!

TOYS AND STUFF FROM HOME

Getting out and meeting new people all the time can be overwhelming for some kids - and adults. Having familiar things from home, once your shipment arrives,

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

can be reassuring.

"We tried to let them bring as much of their own stuff as possible and toys they no longer needed we sold before we left and allowed the boys to spend the money once they were here on new things ( bit of an

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

incentive !). We brought all their DVD collection (which was quite large) and bought a multi region player here so they can watch all their DVD's and one's that people send over from the UK. We wished we had bought a uk tv and

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

their gameplayer too (they can be used with a step up transformer) as it is expensive to replace video games if you have a lot."

FINAL THOUGHTS

Writing this newsletter brought back to me the whole experience of moving. Our te

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

nagers all settled in well and though we all face challenges in doing this, the younger you are the easier it is.

If you are interested in moving to British Columbia, with or without kids, then we'd be very pleased to help you

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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