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Some of you know about this, some of you don't. Either way I'm going to give you the basics of compounding, plus a couple of new slants on the concept. I suggest you read The Magic of Compounding not just once, but several times. If you have ch

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ildren, print this write-up and give it to them to read. If they master this concept they will become rich.

The Basics

Compounding describes how numbers, or money, can grow. Numbers can grow in an arithmetic progression, for example 2,4,6,8,1

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

0,12 or 3,6,9,12,15,18, where one unit is added on at each step in the progression and that action provides the growth, or, numbers can grow exponentially, 2,4,8,16,32,64. In an exponential progression the increase comes by doubling the number

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

t each step in the progression. See the difference? This is compounding.

Now the really amazing part, the magic, comes when you see how fast compounding will make money grow. And guess what! That's right, I've got a little game to play with yo

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

u, a little story to tell, that will illustrate this principle. This puzzle is as old as J.P. Morgan's moustache comb, so if you've already been schooled in compounding you've heard it before. But didn't I tell you to read this section several

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

times? OK, then, solve the puzzle with us once more while I tell it for the first time to the children for whom "The Magic of Compounding" has just been printed out.

The Puzzle

I'm a wealthy and generous man, and I want to hire you to work fo

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

me for one month. Since I'm also flexible, I give you a choice: you can choose to be payed the entire month's salary up front on the first day of your employment, or, I will pay you 1 cent the first day and I'll double your pay every day for t

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

he rest of the month, but you won't get the money until the last day of the month. So on the first day you'll work 8 whole hours and you'll have 1cent coming to you. But on the second day you'll earn 2cents. Hold on, it gets better, the 3rd day

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

with me you'll have earned 4 cents, the day after that 8 cents and so on. Saturdays and Sundays are included just to give you a chance. Oh, by the way, if you take your pay all at once on the first day I'll give you a million bucks ($1,000,000

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

00) cash. Seems like an easy choice, doesn't it?

Well, you decide for yourself . Now let's look at how much the individual who picked the penney-a-day plan are going to have at month's end. Remember, on the one hand $1,000,000.00. On the other

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

hand:

Day  Amount 
 1        $ 0.01
 2        $ 0.02
 3        S 0.04
 4        $ 0.08
 5        $ 0.16
 6        $ 0.32
 7        $ 0.64
 8        $ 0.28

Hey folks, it's day eight, you're up to $1.28 and you only have a month. Ma

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ybe you are better off taking the one shot deal, the million dollars.

Let's see what happens:

Day  Amount 
 9        $ 2.56
 10      $ 5.12
 11      $ 10.24
 12      $ 20.48
 13      $ 40.96
 14      $ 81.82
 15      $ 163.84
 16      $

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

27.68 17 $ 655.36 18 $ 1310.72 19 $ 2621.44 20 $ 5242.88

By the way, did any of you ask me what month of the year we're in? Is it February with 28 days, or leap year with 29 days, or September with 30 days, or Dec

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ember with 31 days? You should realize that it's going to make a difference. Do you want the million dollars? Ask your kids again which they would choose?

Let's continue:

Day Amount 
 21     $ 10,485.76
 22     $ 20,971.52
 23     $ 41,9

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

43.04 24 $ 83,886.08 25 $ 167,772.16 26 $ 335,544.32 27 $ 671,772.16 28 $ 1,342,177.28 29 $ 2,684,354.56 30 $ 5,368,709.12 31 $ 10,737,418.24

If you work for me in September with 30 days you make o

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

er $5,000,000. In December it's over $10,000,000! I have never met the child who didn't leap at the $1,000,000 on day one. This is because human brains think arithmetically, not exponentially. You might say that we are hardwired to think in th

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

is linear way, that the software in our brains compels us to think about progressions as being simple arithmetic ones. Luckily though, how we think about things, our prejudices, our attitudes, and our mindsets, can all be changed and worked wit

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

h. We can update the software! We can consciously change the way we think about numbers, money and investing by absorbing new information, namely, that when you make your money compound you can get rich sooner rather than later.

Teach your chi

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

dren to live a balanced life, and also help them master this concept and you will have very happy and very rich children. In stocks I show you how to make money at the bottom by buying depressed securities that are going to come right back, mak

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ing you a fortune as they rocket off the bottom. In the future I will also show you how to make money with the Warren Buffet concept, or classical Graham and Dodd analysis. In the mean time, good luck with understanding the magic of compounding

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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A higher proportion of money is wasted on training which is inappropriate or just downright poor than almost any other corporate expense. I have seen organisations make the same mistakes with training all over the world. Here are my top ten.

Making money online is not for the RICH and internet savvy people. Anyone can learn to make money online by following some simple instructions and taking the time to really understand what internet marketing is all about. Read this article to find out a sure fire way to accelerate your learning curve and be on your way to a successful career in internet marketing. It can be done!

You can find lots of information on the Internet about how to create a blog. There are recommendations about which tool to use and how to design something that's reader-friendly. But what happens once your blog is constructed? The cold blank page stares back at you on a daily basis.

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